Selective Serotonin Reuptake Inhibitors (SSRIs) for Bipolar
cont. from
Your doctor may prescribe newer antidepressants known as
SSRIs (selective
serotonin reuptake inhibitors) for treating severe depression in
bipolar
disorder. They are usually prescribed along with lithium.
SSRIs are believed to work by boosting levels of the brain chemical
serotonin.
This class of antidepressants includes:
Most antidepressants take several weeks to start working. Though the first
one that is prescribed works in the majority of people, others may need to try
two or three to find the right one. Your doctor may also prescribe a sedative to
help relieve anxiety, agitation, or sleep problems while the antidepressant
begins to work.
SSRI Side Effects
Side effects of SSRIs are generally milder than those of the older classes of
antidepressants. Studies indicate some people taking SSRIs developed painful
headaches and tooth grinding. Their symptoms went away with the addition of the
anti-anxiety drug Buspar (buspirone).
Common side effects may include:
- Nausea
- Nervousness
- Insomnia
- Diarrhea
- Rash
- Agitation
- Erectile dysfunction
- Loss of libido
- Weight gain or loss
The Food and Drug Administration (FDA) recommends close observation of people
treated with these medications for worsening depression or the emergence of
suicidal tendencies. It is unclear whether antidepressants contribute to the
emergence of suicidal thinking and behavior. However, the FDA indicates a need
for careful monitoring of patients being treated with these drugs -- especially
at the beginning of therapy and during dose changes.
continue: MAOI Antidepressants
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Reviewed: 04/2006
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