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Maintaining Stability Over the Long-Term

Maintenance Treatment for Bipolar Disorder

cont. from

After remission from an acute episode, a person is at high risk of relapse for about six months. Thus, maintenance (ongoing) therapy is often recommended.

Anyone who has experienced two to three episodes of bipolar disorder is considered a long-term -- if not lifetime -- bipolar patient. That person should have maintenance therapy. Once your doctor has helped stabilize the moods of the acute phase of the disorder (either a manic or depressive episode), drug therapy is continued indefinitely -- often at lower doses.

It is important to remember this: Even if you have been without bipolar symptoms for several months, do not stop taking your medications. Your doctor may lower your doses, but discontinuation of medications will put you at risk for recurrence of bipolar symptoms.

Lamictal and lithium are the only two drugs that have been approved specifically for maintenance therapy for bipolar disorder. However, many other drugs used to treat manic episodes are also used for maintenance treatment.

These drugs include:

A combination of these drugs may also be used.

Lamictal

Lamictal was recently approved by the FDA for the maintenance treatment of adults with bipolar disorder. It has been found to help delay bouts of depression, mania, hypomania, and mixed episodes in those being treated with standard therapy. It is especially effective in the maintenance treatment of bipolar depression. It is the first FDA-approved therapy since lithium for maintenance in bipolar disorder.

Lamictal is considered a mood-stabilizing anticonvulsant and is most commonly prescribed to prevent or control seizures in the treatment of epilepsy. Recent studies have shown it may possess antidepressant effects in bipolar disorder; therefore, the FDA approved it for maintenance treatment.

Lamictal Side Effects

The drug most often comes in chewable form. It adds to the effects of other central nervous system suppressants such as alcohol -- and to those found in many antihistamines, cold medications, pain medications, and muscle relaxants. Check with your doctor before taking any of these.

Three out of every 1,000 people taking this medication will develop a rash. Sometimes the rash can prove serious or even fatal. If a rash develops, this medication should be stopped immediately.

Common side effects include:

  • Headache
  • Dizziness
  • Diarrhea
  • Dream abnormalities
  • Itching
  • Vision difficulties

Medication errors have occurred in filling Lamictal prescriptions because other medications have similar names, like Lamisil, lamivudine, Ludiomil, labetalol, and Lomotil. To avoid confusion, make sure the drug name is clearly written on your prescription.

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continue: Lithium for Bipolar Maintenance Treatment

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Reviewed: 04/2006



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