By Jonathan Shay, M.D., Ph.D.
Staff Psychiatrist, Boston VA Outpatient Clinic

Ed. Note: This article is applicable to anyone who seeks to understand the role of medication within the treatment framework of PTSD. Although it specifically addresses the veteran community, we have found the information given to be extremely valuable and well-suited for any reader seeking information on this topic.

A. Point of view

Everything I say here is my point of view, and carries no claim of special authority. Also, what I say here is no way complete. I have left out many important subjects, such as drug interactions, what medical conditions forbid the use of a given drug, overdoses and toxicity, and most specific side-effects. Also, many psychiatrists who also care about combat veterans will disagree with what I say here, particularly about the benzodiazepines like Ativan. Combat PTSD is moral, social, philosophical, and spiritual injury. The biological nature of human beings is to be moral, social, philosophical, and spiritual, so the injury also shows itself as medical disorders.

Healing is psychological, social, spiritual -- no medicine can cure combat PTSD. However, healing can never mean a return to 17-year old innocence. Healing means building a good human life with others -- a life that a veteran can embrace as his own.

Combat trauma brings about long-lasting changes in brain chemistry. We do not know whether these are permanent or can be reversed by psychological/social healing. A few existing medications can help some men with some symptoms of PTSD. We also do not know whether this changes the long-term outcome for the better, but the human payoff in reduced suffering is unmistakable.

B. A brief course in pharmacology

1. Therapeutic effects (benefits) and side-effects

   Drugs are dumb chemicals -- they don't know what they are. They aren't born in a laboratory with a word spelled out across their foreheads "Anti-depressant!" or something like that. Most have been discovered by accident. Almost every drug known has multiple effects on the body. Which effect is a therapeutic (beneficial or main) effect and which is an unwanted side-effect is a human decision, not a chemical decision.

   Illustrations: Think of the well-known drug Elavil (generic name: amitriptylene). What is it? An anti-depressant you say? Why is it used in the Intensive Care Unit to stabilize the heart beat of certain patients? Not because depression causes their irregular heart beat. Why is it used by neurologists to treat migraine? Not because depression causes migraine -- and the doses that work for migraine are usually too small to touch a depression. The point is, of course that a drug doesn't know what it is. Its successful human uses make it an anti-depressant, a migraine drug, an anti-arrhythmic.

   What about side-effects? Again, this is a matter of the human purposes involved. Think of the anti-depressant trazodone (most common trade name: Desyrel). Its most prominent side-effect is drowsiness. I prescribe trazodone fairly often as a sleep medication to veterans who are on fluoxetine. It has the advantage that it doesn't lose its effect with repeated use (which also means there's little withdrawal syndrome when the veteran stops it), and it's almost useless as a pill to kill yourself with. So here the side-effect is the main effect and the anti-depressant effect is a side-effect. -- Is anybody confused yet?

   Important to remember: When a drug has several different effects, each effect has its own way of unfolding in time. How long a drug takes to produce its different effects, is often different for each effect. The side-effects may hit immediately and the main effect only develop after several weeks! With another drug it's the opposite, with the main effect coming on immediately and the side effects happening later. An analogy: Think of a plant on your window sill. You've been away for the weekend and its gotten dry and droopy. You give it water and the leaves begin to respond almost as soon as the water goes on -- the plant responds as soon as the water reaches the roots. If the roots dry out, again the plant wilts again. This is like a pharmacokinetic effect. If you put some fertilizer in the water, on the other hand, this reaches the roots as fast as the water reaches them, but you may not see any result for days or weeks. This is because the plant has to build new parts in its own cells. This is like a pharmaco-dynamic effect.

   Example: Most antidepressants reach the brain quickly, but take several weeks to have an anti-depressant effect. This is probably because the changes that have to take place in the cells take that long to happen. However, some side-effects like a dry mouth or drowsiness happen quickly because they do not require cells to make anything new, but only to do what they're already doing faster or slower.

continue: Withdrawal Effects From Sedating Drugs

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Reviewed: 04/2006