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Vitamin B1, also called thiamine, is one of eight water-soluble B vitamins.
All B vitamins help the body to convert carbohydrates into glucose (sugar),
which is "burned" to produce energy. These B vitamins, often referred to as B
complex vitamins, are essential in the breakdown of fats and protein. B complex
vitamins also play an important role in maintaining muscle tone along the wall
of the digestive tract and promoting the health of the nervous system, skin,
hair, eyes, mouth, and liver.
Similar to some other B complex vitamins, thiamine is considered an
"anti-stress vitaimin" because it is believed to enhance the activity of the
immune system and improve the body's ability to withstand stressful conditions.
Thiamine is found in both plants and animals and plays a crucial role in
certain metabolic reactions, particularly, as mentioned, the conversion of
carbohydrates (starches) into energy. For example, thiamine is essential during
exercise, when energy expenditure is high.
Thiamine deficiency is rare, but tends to occur in people who get most of
their calories from sugar or alcohol. Individuals with thiamine deficiency have
difficulty digesting carbohydrates. As a result, a substance called pyruvic acid
builds up in the bloodstream, causing a loss of mental alertness, difficulty
breathing, and heart damage. In general, thiamine supplements are primarily used
to treat this deficiency known as beriberi.
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Beriberi
The most important use of thiamine is in the treatment of beriberi, a condition
caused by a deficiency of thiamine in the diet. Symptoms include swelling,
tingling or burning sensation in the hands and feet, confusion, difficulty
breathing (from fluid in the lungs), and uncontrolled eye movements (called
nystagmus).
Wernicke-Korsakoff syndrome
Wernicke-Korsakoff syndrome is a brain disorder caused by thiamine deficiency.
Replacing thiamine alleviates the symptoms of this syndrome. Wernicke-Korsakoff
is actually two disorders in one: (1) Wernicke's disease involves damage to
nerves in the central and peripheral nervous systems and is generally caused by
malnutrition (particularly a lack of thiamine) associated with habitual alcohol
abuse, and (2) Korsakoff syndrome is characterized by memory impairment with
various symptoms of nerve damage. High doses of thiamine can improve muscle
incoordination and confusion associated with this disease, but only rarely
improves the memory loss.
Cataracts
Dietary and supplemental vitamin B2, along with other nutrients, is important
for normal vision and prevention of cataracts (damage to the lens of the eye
which can lead to cloudy vision). In fact, people with plenty of protein and
vitamins A, B1, B2, and B3 (niacin) in their diet are less likely to develop
cataracts. Plus, taking additional supplements of vitamins C, E, and B complex
(particularly the B1, B2, B9 [folic acid], and B12 [cobalamin] in the complex )
may further protect the lens of your eyes from developing cataracts.
Burns
It is especially important for people who have sustained serious burns to obtain
adequate amounts of nutrients in their daily diet. When skin is burned, a
substantial percentage of micronutrients may be lost. This increases the risk
for infection, slows the healing process, prolongs the hospital stay, and even
increases the risk of death. Although it is unclear which micronutrients are
most beneficial for people with burns, many studies suggest that a multivitamin
including the B complex vitamins may aid in the recovery process.
Heart failure
Thiamine may be related to heart failure in two ways. First, low levels of
thiamine may contribute to the development of congestive heart failure (CHF). On
the flip side, people with severe heart failure can lose a significant amount of
weight including muscle mass (called wasting or cachexia) and become deficient
in many nutrients. It is not known whether taking thiamine supplements would
have any bearing on the development or progression of CHF and cachexia. Eating a
balanced diet, including thiamine, and avoiding things that deplete this
nutrient, such as high amounts of sugar and alcohol, seems prudent, particularly
for those at the early stages of CHF.
Other
Some scientists have speculated that thiamine may have some benefit in treating
Alzheimer's Disease. This theory is based on the effects that this nutrient has
on the brain and the symptoms that people develop when deficient in thiamine.
The studies on this subject to date are limited in number and inconclusive,
however. Much more research would be needed before anything could be said
regarding a possible use for thiamine in treating
Alzheimer's Disease.
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Limited quantities of thiamine can be found in most foods, but large amounts
of this vitamin can be found in pork and organ meats. Other good dietary sources
of thiamine include whole-grain or enriched cereals and rice, wheat germ, bran,
brewer's yeast, and blackstrap molasses.
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Vitamin B1 can be found in multivitamins (including children's chewable and
liquid drops), B complex vitamins, or can be sold individually. It is available
in a variety of forms including tablets, softgels, and lozenges. It may also be
labeled as thiamine hydrochloride or thiamine mononitrate.
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How to Take It Vitamin B1
As with all medications and supplements, check with a healthcare provider
before giving vitamin B1 supplements to a child.
Daily recommendations for dietary vitamin B1 are listed below.
Pediatric
- Newborns to 6 months: 0.2 mg (adequate intake)
- Infants 7 months to 1 year: 0.3 mg (adequate intake)
- Children 1 to 3 years: 0.5 mg (RDA)
- Children 4 to 8 years: 0.6 mg (RDA)
- Children 9 to 13 years: 0.9 mg (RDA)
- Males 14 to 18 years: 1.2 mg (RDA)
- Females 14 to 18 years: 1 mg (RDA)
Adult
- Males 19 years and older: 1.2 mg (RDA)
- Females 19 years and older: 1.1 mg (RDA)
- Pregnant females: 1.4 mg (RDA)
- Breastfeeding females: 1.5 mg (RDA)
Doses for conditions like beriberi and Wernicke-Korsakoff syndrome are
decided by a healthcare practitioner in an appropriate clinical setting. For
Wernicke-Korsakoff syndrome, thiamine is administered by venous injection.
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Because of the potential for side effects and interactions with medications,
dietary supplements should be taken only under the supervision of a
knowledgeable healthcare provider.
Oral vitamin B1 is generally nontoxic. Stomach upset can occur at very high
doses (much higher than the recommended daily amount).
Taking any one of the B complex vitamins for a long period of time can result
in an imbalance of other important B vitamins. For this reason, it is generally
important to take a B complex vitamin with any single B vitamin.
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If you are currently being treated with any of the following medications, you
should not use vitamin B1 without first talking to your healthcare provider.
Antibiotics, Tetracycline
Vitamin B1 should not be taken at the same time as the antibiotic tetracycline
because it interferes with the absorption and effectiveness of this medication.
Vitamin B1 either alone or in combination with other B vitamins should be taken
at different times from tetracycline. (All vitamin B complex supplements act in
this way and should therefore be taken at different times from tetracycline.)
Antidepressant medications, Tricylic
Taking vitamin B1 supplements may improve treatment with antidepressants such as
nortriptyline, especially in elderly patients. Other medications in this class
of antidepressants include desimpramine and
imipramine.
Chemotherapy
Although the significance is not entirely clear, laboratory studies suggest that
thiamine may inhibit the anti-cancer activity of chemotherapy agents. How this
will ultimately prove relevant to people is not known. However, it may be wise
for people undergoing chemotherapy for cancer to not take large doses of vitamin
B1 supplements.
Digoxin
Laboratory studies suggest that digoxin (a medication used to treat heart
conditions) may reduce the ability of heart cells to absorb and use vitamin B1;
this may be particularly true when digoxin is combined with furosemide (a loop
diuretic).
Diuretics
Diuretics (particularly furosemide, which belongs to a class called loop
diuretics) may reduce the levels of vitamin B1 in the body. In addition, similar
to digoxin, furosemide may diminish the heart's ability to absorb and utilize
vitamin B1, especially when these two medications are combined.
Scopolamine
Vitamin B1 may help reduce some of the side effects associated with scopolamine,
a medication commonly used to treat motion sickness.
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