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Common Forms: calcium pantothenate, pantethine, panthenol
Vitamin B5, also called pantothenic acid, is one of eight water-soluble B
vitamins. All B vitamins help the body to convert carbohydrates into glucose
(sugar), which is "burned" to produce energy. These B vitamins, often referred
to as B complex vitamins, are essential in the breakdown of fats and protein. B
complex vitamins also play an important role in maintaining muscle tone in the
gastrointestinal tract and promoting the health of the nervous system, skin,
hair, eyes, mouth, and liver.
In addition to playing a role in the breakdown of fats and carbohydrates for
energy, Vitamin B5 is critical to the manufacture of red blood cells as well as
sex and stress-related hormones produced in the adrenal glands (small glands
that sit atop of the kidneys). Vitamin B5 is also important in maintaining a
healthy digestive tract and it helps the body use other vitamins (particularly
B2 [riboflavin]) more effectively. It is sometimes referred to as the
"anti-stress vitamin" because it is believed to enhance the activity of the
immune system and improve the body's ability to withstand stressful conditions.
Pantethine, an active stable form of vitamin B5, has been gaining attention
in recent years as a possible treatment for high cholesterol. Further studies
are needed to confirm these findings, however, Panthanol, another form of
vitamin B5, is often found in hair care products because of the belief that it
makes hair more manageable, softer, and shinier.
Vitamin B5 can be found in all living cells and is widely distributed in
foods so deficiency of this substance is rare. Symptoms of a vitamin B5
deficiency may include fatigue, insomnia, depression, irritability, vomiting,
stomach pains, burning feet, and upper respiratory infections.
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Wound Healing
Studies, primarily in test tubes and animals but a few on people, suggest that
vitamin B5 supplements may speed wound healing, especially following surgery.
This may be particularly true if vitamin B5 is combined with
vitamin C.
Burns
It is especially important for people who have sustained serious burns to obtain
adequate amounts of nutrients in their daily diet. When skin is burned, a
substantial percentage of micronutrients may be lost. This increases the risk
for infection, slows the healing process, prolongs the hospital stay, and even
increases the risk of death. Although it is unclear which micronutrients are
most beneficial for people with burns, many studies suggest that a multivitamin
including the B complex vitamins may aid in the recovery process.
High Cholesterol
Throughout the past twenty years or so, emerging studies of animals and people
have suggested that high doses of pantethine (a stable form of vitamin B5) may
improve cholesterol and triglyceride levels in people with high cholesterol with
or without other risk factors for heart disease (such as diabetes, obesity, and
menopause). The studies to date have included only small numbers of people, but
have been encouraging because not only has pantethine lowered cholesterol and
triglycerides, it has also increased HDL (the "good" kind of cholesterol). Plus,
several of the studies have looked at the use of pantethine in special groups of
people, such as adults on dialysis and children with high cholesterol. More
research is needed in this area to fully understand what value pantethine may
have for treating or preventing high cholesterol.
Other related areas that are under current scientific investigation include
use of pantethine for heart disease and for weight loss.
Arthritis
Although not widely studied to date, there may be some benefit to making sure
that there is an adequate amount of pantothenic acid in the diet or taking extra
vitamin B5 supplements for arthritis.
For example, some researchers report that blood levels of pantothenic acid
are lower in people with rheumatoid arthritis than those without this condition.
A study conducted in 1980 concluded that 2,000 mg/day of calcium pantothenate
improved symptoms of rheumatoid arthritis including morning stiffness and pain.
Further studies are needed to confirm these findings, however.
Similarly, obese patients with osteoarthritis may improve their symptoms if
they receive dietary counseling about appropriate intake of vitamin B5 (as well
as other nutrients) and weight loss.
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Pantothenic acid gets its name from the Greek root pantos, meaning
"everywhere," because it is available in a wide variety of foods. A lot of
vitamin B5 is lost in processing, however. Fresh meats, vegetables, and whole
unprocessed grains have more vitamin B5 than refined, canned, and frozen food.
The best sources of this vitamin are brewer's yeast, corn, cauliflower, kale,
broccoli, tomatoes, avocadolegumes, lentils, egg yolks, beef (especially organ
meats such as liver and kidney), turkey, duck, chicken, milk, split peas,
peanuts, soybeans, sweet potatoes, sunflower seeds, whole-grain breads and
cereals, lobster, wheat germ, and salmon.
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Vitamin B5 can be found in multivitamins, B complex vitamins, or sold
individually under the names pantothenic acid and calcium pantothenate. It is
available in a variety of forms including tablets, softgels, and capsules.
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How to Take Vitamin B5
Recommended daily intakes of dietary vitamin B5 are listed below:
Pediatric
- Infants birth to 6 months: 1.7 mg
- Infants 6 months to 1 year: 1.8 mg
- Children 1 to 3 years: 2 mg
- Children 4 to 8 years: 3 mg
- Children 9 to 13 years: 4 mg
- Adolescents 14 to 18 years: 5 mg
Adult
- 19 years and older: 5 mg
- Pregnant females: 6 mg
- Lactating females: 7 mg
Higher doses may be recommended by a qualified practitioner for the treatment
of specific conditions.
- Rheumatoid arthritis: 2,000 mg/day
- High cholesterol/triglycerides: 300 mg pantethine, 3 times daily (900
mg/day)
- General adrenal support (meaning during times of particular stress): 250
mg pantothenic acid 2 times daily
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Because of the potential for side effects and interactions with medications,
dietary supplements should be taken only under the supervision of a
knowledgeable healthcare provider.
Vitamin B5 should be taken with water, preferably after eating.
Taking any one of the B complex vitamins for a long period of time can result
in an imbalance of other important B vitamins. For this reason, it is generally
important to take a B complex vitamin with any single B vitamin.
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If you are currently being treated with any of the following medications, you
should not use vitamin B5 supplements without first talking to your healthcare
provider.
Antibiotics, Tetracycline
Vitamin B5 should not be taken at the same time as the antibiotic tetracycline
because it interferes with the absorption and effectiveness of this medication.
B vitamins should be taken at different times from tetracycline. (All vitamin B
complex supplements act in this way and should therefore be taken at different
times from tetracycline.)
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Adding vitamins to the mix: skin care products that can benefit the skin
[press release]. American Academy of Dermatology; March 11, 2000.
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supplemental pantothenic acid on wound healing: experimental study in rabbit. Am
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diabetic patients on dialysis with a physiological substance. Am J Nephrol.
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adolescents. Ann NY Acad Sci. 1991;623:275-284.
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hypotriglyceridemic activity of pantethine. Med Hypotheses. 2001;56(3):314-317.
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Reviewed: 01/2006
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